Oxidative Stress And Redox-Based Interventions In Chronic Diseases: A Systematic Review
DOI:
https://doi.org/10.58439/jhrt.v3i2.399Keywords:
Oxidative Stress, Biomarkers, Chronic Diseases, Malondialdehyde, Superoxide Dismutase, 8-OHdG, Systematic ReviewAbstract
Background:
Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defense systems, has emerged as a critical factor in the pathogenesis of various chronic diseases. Understanding its mechanisms and therapeutic implications is essential for developing effective interventions.
Objective:
This review aims to evaluate the role of oxidative stress in chronic diseases and to analyze the efficacy of pharmacological interventions with antioxidant or pro-oxidant properties across cardiovascular, metabolic, neurodegenerative, and oncological disorders.
Methods:
A systematic search was conducted across PubMed, Scopus, and Web of Science for articles published between January 2000 and December 2024. Inclusion criteria encompassed original studies (RCTs, observational, and preclinical) examining oxidative stress biomarkers and therapeutic outcomes. Quality assessment employed validated tools including the Cochrane Risk of Bias Tool, Newcastle-Ottawa Scale, and AMSTAR-2. A narrative synthesis approach was used due to heterogeneity in study designs.
Results:
Malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were the most consistently elevated markers across diseases such as type 2 diabetes mellitus, cardiovascular disease, Parkinson’s disease, COPD, psoriasis, and chronic kidney disease. Antioxidant enzymes—superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH)—were frequently reduced, indicating compromised redox defense. MDA and SOD levels were responsive to lifestyle or pharmacological interventions, highlighting their potential for therapeutic monitoring. Heterogeneity in biomarker assessment methods limited cross-study comparisons.
Conclusion:
Oxidative stress biomarkers demonstrate consistent alterations across chronic diseases, suggesting their utility in disease monitoring and risk stratification. MDA, 8-OHdG, SOD, and CAT are among the most clinically informative markers. Standardized measurement protocols are essential to improve their translational value in redox-based diagnostics and therapeutic evaluation
References
Adah, A. S., Ayo, J. O., Adah, D. A., Nwonuma, C. O., & Lawal, T. A. (2023). Molecular Docking and Experimental Validation of the Effect of Ergothioneine on Heat Shock Protein-70 Following Endurance Exercise by Arabian Stallions. BMC Veterinary Research, 19(1). https://doi.org/https://10.1186/s12917-023-03584-6
Ahmed, S. M. J., Miskeen, E., Awadelgeed, B. A., & Faifi, J. A. A. (2023). The Psychological Impact of the Ongoing COVID-19 Pandemic on Health-Care Workers in Primary Health-Care Centers in Resource-Poor Settings. Journal of Family Medicine and Primary Care, 12(11), 2840–2847. https://doi.org/https://10.4103/jfmpc.jfmpc_2416_22
Bont, J. d., Jaganathan, S., Dahlquist, M., Persson, Å., Stafoggia, M., & Ljungman, P. (2022). Ambient Air Pollution and Cardiovascular Diseases: An Umbrella Review of Systematic Reviews and Meta‐analyses. Journal of Internal Medicine, 291(6), 779–800. https://doi.org/https://10.1111/joim.13467
Cui, Y., Wu, J., Zhang, D., Li, D., Zhang, J., Li, W., Wang, C., Yuan, C., & Liu, Z. (2024). Changes in Chemical Components and Hepatoprotective Effect of RedPanax Notoginsengprocessed by Aspartic Acid Impregnation Treatment. Journal of the Science of Food and Agriculture, 104(10), 6085–6099. https://doi.org/https://10.1002/jsfa.13440
Djurić, T., Djordjević, A., Kuveljić, J., Stefanović, M., Dinčić, E., Kolaković, A., & Živković, M. (2025). Association of Functional Gene Variants in DYSF–ZNF638, MTSS1 and Ferroptosis-Related Genes With Multiple Sclerosis Severity and Target Gene Expression. International Journal of Molecular Sciences, 26(11), 4986. https://doi.org/https://10.3390/ijms26114986
El-Baz, Y. G., Moustafa, A. F. I., Ali, M. A., Eldesoky, G. E., Wabaidur, S. M., & Iqbal, A. (2023). Green Synthesized Silver Nanoparticles for the Treatment of Diabetes and the Related Complications of Hyperlipidemia and Oxidative Stress in Diabetic Rats. Experimental Biology and Medicine, 248(23), 2237–2248. https://doi.org/https://10.1177/15353702231214258
Fan, H., Shen, Y., Ya, R., Mou, Q., Lin, T., Zhu, L., & Ren, T. (2021). Combined Intake of Blueberry Juice and Probiotics Ameliorate Mitochondrial Dysfunction by Activating SIRT1 in Alcoholic Fatty Liver Disease. Nutrition & Metabolism, 18(1). https://doi.org/https://10.1186/s12986-021-00554-3
Fei, Y., Cheng, Y., Wang, X., Ruan, J., Zheng, D., Cao, H., Wang, X., Wang, X., Zhao, X., & Yang, J. (2025). Association Between Brominated Flame Retardants and Obesity: A Mediation Analysis Through Markers of Oxidative Stress and Inflammation. Environmental Health and Preventive Medicine, 30(0), 35. https://doi.org/https://10.1265/ehpm.24-00328
Gao, D., Wang, S., Lin, Y., & Sun, Z. (2020). In Vivo AAV Delivery of Glutathione Reductase Gene Attenuates Anti-Aging Gene Klotho Deficiency-Induced Kidney Damage. Redox Biology, 37, 101692. https://doi.org/https://10.1016/j.redox.2020.101692
Guerrero, L. M., Causado, A. S., & Caballero, A. D. (2020). Especies Reactivas De Oxígeno, Estrés Oxidativo Y Su Relación Con La Destrucción Tisular en Periodontitis. Ces Odontología, 33(2), 112–127. https://doi.org/https://10.21615/cesodon.33.2.10
Hayes, J. D., Dinkova‐Kostova, A. T., & Tew, K. D. (2020). Oxidative Stress in Cancer. Cancer Cell, 38(2), 167–197. https://doi.org/https://10.1016/j.ccell.2020.06.001
Hsu, C., Kao, S., Yen, C., Hsiao, C., Cho, S., Wang, H.-C., Yeh, T., Du, J., Wang, M., Hsieh, T.-Y., Hsiao, S. Y., Tsai, Y., Hung, L.-C., Liu, Y., Chang, K., & Hsiao, H.-H. (2024). Biomarker Potential of Nuclear Nrf2 Activation in the ABC Subtype of Diffuse Large B‑cell Lymphoma. Oncology Letters, 29(1). https://doi.org/https://10.3892/ol.2024.14776
Imam, A., Tunde, A. M., Amin, A., Abdulmajeed, W. I., Attai, A. G., Akorede, A. A., Ijomone, O. M., & Ajao, M. S. (2025). Vitamin E-Valproate Co-Therapy Attenuated Oxidative Stress, Neuroinflammation, Related Cognitive Deficits and Neuronal Damage in Cypermethrin Exacerbated Seizure. https://doi.org/https://10.21203/rs.3.rs-5695471/v1
Kang, S.-H., Hong, J. K., Kim, C., Kim, J. S., & Yoon, I. (2024). REM Sleep Without Atonia and Neurocognitive Function in Isolated REM Sleep Behaviour Disorder: Cross‐sectional and Longitudinal Study. Journal of Sleep Research, 34(2). https://doi.org/https://10.1111/jsr.14336
Laksana, A. S. D., Notopuro, H., & Mustika, A. (2023). Ameliorative Effects of Moringa (Moringa Oleifera Lam.) Leaves Extract on Lead-Induced Oxidative Stress, Hepcidin and Δ-Alad Levels in Rat’s Blood. Pharmacognosy Journal, 14(6), 856–862. https://doi.org/https://10.5530/pj.2022.14.179
Li, Z., Wang, Y., Xu, Q., Ma, J., Li, X., Tian, Y., Wen, Y., & Chen, T. (2023). Ginseng and Health Outcomes: An Umbrella Review. Frontiers in Pharmacology, 14. https://doi.org/https://10.3389/fphar.2023.1069268
Liu, Z., Lu, T., Wu, K., Gu, S., Li, L., Dong, C., & Zhou, Y. (2020). IFI6 Depletion Inhibits Esophageal Squamous Cell Carcinoma Progression Through Reactive Oxygen Species Accumulation via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress. https://doi.org/https://10.21203/rs.3.rs-21256/v1
Long, Y., Shi, H., Ye, J., & Qi, X. (2025). Exploring Strategies to Prevent and Treat Ovarian Cancer in Terms of Oxidative Stress and Antioxidants. Antioxidants, 14(1), 114. https://doi.org/https://10.3390/antiox14010114
Mahboub, H. H., Gad, W. M., Aziz, E. K., Nasr, M. A., Fahmy, E. M., Mansour, D. M., Rasheed, N., Ali, H. S., Ismail, S. H., & Rahman, A. N. A. (2023). Silica Nanoparticles Alleviate the Immunosuppression, Oxidative Stress, Biochemical, Behavioral, and Histopathological Alterations Induced by Aeromonas Veronii Infection in African Catfish (Clarias Gariepinus). Fish Physiology and Biochemistry, 50(2), 767–783. https://doi.org/https://10.1007/s10695-023-01274-6
McCorquodale, C. L., Greening, R., Tulloch, R., & Forget, P. (2023). Opioid Prescribing for Acute Postoperative Pain: An Overview of Systematic Reviews Related to Two Consensus Statements Relevant at Patient, Prescriber, System and Public Health Levels. BMC Anesthesiology, 23(1). https://doi.org/https://10.1186/s12871-023-02243-5
Mohammad, C. A., Ali, K. M., Sha, A. M., & Gul, S. S. (2022). Antioxidant Effects of Curcumin Gel in Experimental Induced Diabetes and Periodontitis in Rats. Biomed Research International, 2022(1). https://doi.org/https://10.1155/2022/7278064
Morelli, R., Conidi, C., Tundis, R., Loizzo, M. R., D’Avella, M., Timpone, R., & Cassano, A. (2022). Production of High-Quality Red Fruit Juices by Athermal Membrane Processes. Molecules, 27(21), 7435. https://doi.org/https://10.3390/molecules27217435
Samura, M., Takada, K., Hirose, N., Kurata, T., Nagumo, F., Uchida, M., Inoue, J., Tanikawa, K., Enoki, Y., Taguchi, K., Matsumoto, K., Ueda, T., Fujimura, S., Mikamo, H., Takesue, Y., & Mitsutake, K. (2023). Comparison of the Efficacy and Safety of Standard‐ and High‐dose Daptomycin: A Systematic Review and Meta‐analysis. British Journal of Clinical Pharmacology, 89(4), 1291–1303. https://doi.org/https://10.1111/bcp.15671
Scrobotă, I., Țig, I., Marcu, A. O., Cicalău, G. I. P., Sachelarie, L., & Iova, G. (2024). Evaluation of Immunohistochemical Biomarkers in Diabetic Wistar Rats With Periodontal Disease. Journal of Personalized Medicine, 14(5), 527. https://doi.org/https://10.3390/jpm14050527
Song, G., Peng, G., Zhang, J., Song, B., Yang, J., Xie, X., Gou, S., Zhang, J., Yang, G., Chi, H., & Tian, G. (2023). Uncovering the Potential Role of Oxidative Stress in the Development of Periodontitis and Establishing a Stable Diagnostic Model via Combining Single-Cell and Machine Learning Analysis. Frontiers in Immunology, 14. https://doi.org/https://10.3389/fimmu.2023.1181467
Syarifah, A. S., Sudjarwo, S. A., Hendarto, H., & I’tishom, M. R. (2020). Nanocurcumin Protective Effect on Lipid Peroxide of Lead Acetate Induced White Rats (Rattus Norvegicus) Ovarian Granulosa Cells. Indian Journal of Forensic Medicine & Toxicology. https://doi.org/https://10.37506/ijfmt.v14i4.11581
Tang, L., Zeng, Z., Zhou, Y., Wang, B., Zou, P., Wang, Q., Ying, J., Wang, F., Li, X., Xu, S., Zhao, P., & Li, W. (2021). Bacillus Amyloliquefaciens SC06 Induced AKT–FOXO Signaling Pathway-Mediated Autophagy to Alleviate Oxidative Stress in IPEC-J2 Cells. Antioxidants, 10(10), 1545. https://doi.org/https://10.3390/antiox10101545
Wang, T., Chen, X., Li, H., Chen, W., Xu, Y., Yao, Y., Zhang, H., Han, Y., Zhang, L., Que, C., Gong, J., Qiu, X., & Zhu, T. (2022). Pro-Thrombotic Changes Associated With Exposure to Ambient Ultrafine Particles in Patients With Chronic Obstructive Pulmonary Disease: Roles of Lipid Peroxidation and Systemic Inflammation. Particle and Fibre Toxicology, 19(1). https://doi.org/https://10.1186/s12989-022-00503-9
Xiong, K., Yang, P., Wei, W., Li, J., Cui, Y., Li, Y., & Tang, B. (2023). Periodontitis Contributes to COPD Progression via Affecting Ferroptosis. BMC Oral Health, 23(1). https://doi.org/https://10.1186/s12903-023-03397-x
Yıldız, H. (2022). Effects of Glutathione on Mitochondrial DNA and Antioxidant Enzyme Activities in Drosophila Melanogaster. International Journal of Secondary Metabolite, 9(4), 377–386. https://doi.org/https://10.21448/ijsm.1084592
Zunaidy, N. A. A., Al‐Khalifa, A. S., Alhussain, M. H., Althwab, S. A., Mohammed, M. A., & Faris, M. E. (2024). The Effect of Ramadan Intermittent Fasting on Anthropometric, Hormonal, Metabolic, Inflammatory, and Oxidative Stress Markers in Pre-and Post-Menopausal Women: A Prospective Cohort of Saudi Women. Frontiers in Nutrition, 11. https://doi.org/https://10.3389/fnut.2024.1437169
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